Gout is a metabolic disease of heterogeneous nature, associated with adnormal amounts of urates in the body and characterized early by a recurring acute arthritis, usually monarticular, and later by chronic deforming arthritis. The associated hyperuricemia is due to overproduction or underexcretion of uric acid - sometimes both. Secondary gout, Which may have a heritable component, is related to acquired causes of hyperuricemia, eg, diuretic use, cyclosporine use, hemoglobinopathies, chronic renal disease, hypothyroidism and lead poisoning. About 90% of patients with primary gout are men, usually over 30 years of age. In women the onset is usually postmenopausal. The metatarsophalangeal joint of the great toe is the most susceptible joint although others; especially those of the feet, ankles, and knees are involved in gouty arthritis. More than one joint may occasionally be affected. It is a chronic disorder. |